Brett I. Bell

Research

Highlighted

Whole Abdominal Pencil Beam Scanned Proton FLASH Increases Acute Lethality
Whole Abdominal Pencil Beam Scanned Proton FLASH Increases Acute Lethality
Brett I. Bell, Christian Velten, Michael Pennock, Minglei Kang, Kathryn E. Tanaka, …, Charles B. Simone, Weng-Lang Yang, Wolfgang A. Tomé, Haibo Lin, Chandan Guha
International Journal of Radiation Oncology*Biology*Physics  ·  01 Feb 2025  ·  doi:10.1016/j.ijrobp.2024.09.006
Orthovoltage X-Rays Exhibit Increased Efficacy Compared with γ-Rays in Preclinical Irradiation
Orthovoltage X-Rays Exhibit Increased Efficacy Compared with γ-Rays in Preclinical Irradiation
Brett I. Bell, Justin Vercellino, N. Patrik Brodin, Christian Velten, Lalitha S.Y. Nanduri, …, Laibin Liu, Wolfgang A. Tomé, Weng-Lang Yang, Richard Kolesnick, Chandan Guha
Cancer Research  ·  03 Aug 2022  ·  doi:10.1158/0008-5472.CAN-22-0656

All

2025

Carbon Ion Therapy-Induced Local Control of Pancreatic Cancer is Dependent on the Presence of the Adaptive Anti-Tumor Immunity
Carbon Ion Therapy-Induced Local Control of Pancreatic Cancer is Dependent on the Presence of the Adaptive Anti-Tumor Immunity
S. Eskandarian, M. Moustafa, M. Akbarpour, B.I. Bell, H.J. Meyer, …, J. Schlegel, I. Dokic, M. Knoll, C. Guha, A. Abdollahi
International Journal of Radiation Oncology*Biology*Physics  ·  01 Sep 2025  ·  doi:10.1016/j.ijrobp.2025.06.2566
Understanding Vaccine Disparities in the Bronx, New York, Through a Mixed Methods Analysis of Community and Provider Perspectives
Understanding Vaccine Disparities in the Bronx, New York, Through a Mixed Methods Analysis of Community and Provider Perspectives
Brett I. Bell, Sarah Hill, Justin Olivera, Valerie Fong, Michelle Schumacher, …, Tova Niderberg, Taneisha Sinclair, Damara N. Gutnick, Oladimeji A. Oki, Cara Stephenson-Hunter
AJPM Focus  ·  01 Aug 2025  ·  doi:10.1016/j.focus.2025.100373
Loss of CARM1 alters the developmental programming of Glioma stem-like cells and creates a druggable NGFR NTRK dependency
Loss of CARM1 alters the developmental programming of Glioma stem-like cells and creates a druggable NGFR/NTRK dependency
Dejauwne L. Young, Jennifer Aguilan, Ronald Cutler, Stephanie Stransky, Joseph D. DeAngelo, …, David Shechter, Philip J. Tofilon, Richard E. Phillips, Chandan Guha, Simone Sidoli
Cold Spring Harbor Laboratory  ·  17 Apr 2025  ·  doi:10.1101/2025.04.11.647869
FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin, and bone
FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin, and bone
Ioannis I. Verginadis, Anastasia Velalopoulou, Michele M. Kim, Kyle Kim, Ioannis Paraskevaidis, …, James M. Metz, Amit Maity, Keith A. Cengel, Constantinos Koumenis, Theresa M. Busch
Radiotherapy and Oncology  ·  01 Apr 2025  ·  10.1016/j.radonc.2025.110744
Whole Abdominal Pencil Beam Scanned Proton FLASH Increases Acute Lethality
Whole Abdominal Pencil Beam Scanned Proton FLASH Increases Acute Lethality
Brett I. Bell, Christian Velten, Michael Pennock, Minglei Kang, Kathryn E. Tanaka, …, Charles B. Simone, Weng-Lang Yang, Wolfgang A. Tomé, Haibo Lin, Chandan Guha
International Journal of Radiation Oncology*Biology*Physics  ·  01 Feb 2025  ·  doi:10.1016/j.ijrobp.2024.09.006

2024

Immunological Effectiveness of Carbon Ion Radiotherapy in Pancreatic Cancer
Immunological Effectiveness of Carbon Ion Radiotherapy in Pancreatic Cancer
B.I. Bell, S. Pandey, B. Malachowska, M.M. Schumacher, D. Young, …, M. Moustafa, S. Sidoli, P. Guida, A. Abdollahi, C. Guha
International Journal of Radiation Oncology*Biology*Physics  ·  01 Oct 2024  ·  doi:10.1016/j.ijrobp.2024.07.2303
Validation and reproducibility of in vivo dosimetry for pencil beam scanned FLASH proton treatment in mice
Validation and reproducibility of in vivo dosimetry for pencil beam scanned FLASH proton treatment in mice
Alex Bookbinder, Balaji Selvaraj, Xingyi Zhao, Yunjie Yang, Brett I. Bell, …, J. Isabelle Choi, Haibo Lin, Charles B. Simone, Chandan Guha, Minglei Kang
Radiotherapy and Oncology  ·  01 Sep 2024  ·  doi:10.1016/j.radonc.2024.110404
Radiobiological Investigations of Orthovoltage X-Rays, FLASH Proton Therapy, and Carbon Ion Radiotherapy
Radiobiological Investigations of Orthovoltage X-Rays, FLASH Proton Therapy, and Carbon Ion Radiotherapy
Albert Einstein College of Medicine  ·  18 Jul 2024  ·  [no id info]
FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone
FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone
Ioannis I. Verginadis, Anastasia Velalopoulou, Michele M. Kim, Kyle Kim, Ioannis Paraskevaidis, …, James M. Metz, Amit Maity, Keith A. Cengel, Constantinos Koumenis, Theresa M. Busch
Cold Spring Harbor Laboratory  ·  11 Jul 2024  ·  doi:10.1101/2024.07.08.602528
Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome
Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome
Justin Vercellino, Beata Małachowska, Shilpa Kulkarni, Brett I. Bell, Shahin Shajahan, …, Amit K. Verma, Sanchita P. Ghosh, Weng-Lang Yang, Paul S. Frenette, Chandan Guha
Springer Science and Business Media LLC  ·  19 Feb 2024  ·  doi:10.21203/rs.3.rs-3946910/v1
Role of chemokine receptors in gastrointestinal mucosa
Role of chemokine receptors in gastrointestinal mucosa
Brett Bell, Kevin Flores-Lovon, Luis A. Cueva-Chicaña, Rodney Macedo
International Review of Cell and Molecular Biology  ·  01 Jan 2024  ·  doi:10.1016/bs.ircmb.2024.02.003

2023

Commissioning a 250 MeV research beamline for proton FLASH radiotherapy preclinical experiments
Commissioning a 250 MeV research beamline for proton FLASH radiotherapy preclinical experiments
Yunjie Yang, Minglei Kang, Chin‐Cheng Chen, Lei Hu, Francis Yu, …, Michael Pennock, Wolfgang A. Tome, Chanda Guha, Charles B. Simone, Haibo Lin
Medical Physics  ·  29 Mar 2023  ·  doi:10.1002/mp.16364
Radiosensitization beyond DNA damage: Monte Carlo simulations of realistic nanomaterial biodistributions
Radiosensitization beyond DNA damage: Monte Carlo simulations of realistic nanomaterial biodistributions
Christian Velten, Brett Bell, Wolfgang A. Tomé
arXiv  ·  01 Jan 2023  ·  doi:10.48550/arXiv.2312.07688

2022

Preclinical models of radiation-induced cardiac toxicity: Potential mechanisms and biomarkers
Preclinical models of radiation-induced cardiac toxicity: Potential mechanisms and biomarkers
Alexandra D. Dreyfuss, Anastasia Velalopoulou, Harris Avgousti, Brett I. Bell, Ioannis I. Verginadis
Frontiers in Oncology  ·  12 Oct 2022  ·  doi:10.3389/fonc.2022.920867
Immune responses in COVID-19 and tuberculosis coinfection: A scoping review
Immune responses in COVID-19 and tuberculosis coinfection: A scoping review
Kevin Flores-Lovon, Brando Ortiz-Saavedra, Luis A. Cueva-Chicaña, Shalom Aperrigue-Lira, Elizbet S. Montes-Madariaga, David R. Soriano-Moreno, Brett Bell, Rodney Macedo
Frontiers in Immunology  ·  26 Aug 2022  ·  doi:10.3389/fimmu.2022.992743
Orthovoltage X-Rays Exhibit Increased Efficacy Compared with γ-Rays in Preclinical Irradiation
Orthovoltage X-Rays Exhibit Increased Efficacy Compared with γ-Rays in Preclinical Irradiation
Brett I. Bell, Justin Vercellino, N. Patrik Brodin, Christian Velten, Lalitha S.Y. Nanduri, …, Laibin Liu, Wolfgang A. Tomé, Weng-Lang Yang, Richard Kolesnick, Chandan Guha
Cancer Research  ·  03 Aug 2022  ·  doi:10.1158/0008-5472.CAN-22-0656
Acute and late effects of focal irradiation of the intestine using a novel volume-scaled mouse model
Acute and late effects of focal irradiation of the intestine using a novel volume-scaled mouse model
University of Pennsylvania  ·  20 Jun 2022  ·  [no id info]
Abstract 1319: Complement activation in pancreatic ductal adenocarcinoma
Abstract 1319: Complement activation in pancreatic ductal adenocarcinoma
Brett I. Bell, Sanjay Pandey, Patrik Asp, Chandan Guha
Cancer Research  ·  15 Jun 2022  ·  doi:10.1158/1538-7445.am2022-1319
A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression
A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression
Ioannis I. Verginadis, Harris Avgousti, James Monslow, Giorgos Skoufos, Frank Chinga, …, Sandra Ryeom, J. Alan Diehl, Serge Y. Fuchs, Ellen Puré, Constantinos Koumenis
Nature Cell Biology  ·  01 Jun 2022  ·  doi:10.1038/s41556-022-00918-8
Rapid Mobilization of Medical Student Volunteers to Administer Vaccines During the COVID-19 Pandemic
Rapid Mobilization of Medical Student Volunteers to Administer Vaccines During the COVID-19 Pandemic
Taneisha Sinclair, Brett I. Bell, Karol Perez, Daniel Klyde, Mitchell Veith, Rachel Weinstock, Todd Cassese, Joshua D. Nosanchuk
Journal of Medical Education and Curricular Development  ·  01 Jan 2022  ·  doi:10.1177/23821205211073092

2019

Interleukin 6 Signaling Blockade Exacerbates Acute and Late Injury From Focal Intestinal Irradiation
Interleukin 6 Signaling Blockade Exacerbates Acute and Late Injury From Focal Intestinal Irradiation
Brett I. Bell, Sravya Koduri, Carlo Salas Salinas, James Monslow, Ellen Puré, Edgar Ben-Josef, Constantinos Koumenis, Ioannis I. Verginadis
International Journal of Radiation Oncology*Biology*Physics  ·  01 Mar 2019  ·  doi:10.1016/j.ijrobp.2018.10.007

2018

Assessing the Validity of Clinician Advice That Patients Avoid Use of Topical Agents Before Daily Radiotherapy Treatments
Assessing the Validity of Clinician Advice That Patients Avoid Use of Topical Agents Before Daily Radiotherapy Treatments
Brian C. Baumann, Ioannis I. Verginadis, Chuan Zeng, Brett Bell, Sravya Koduri, Carolyn Vachani, Kelly M. MacArthur, Timothy D. Solberg, Constantinos Koumenis, James M. Metz
JAMA Oncology  ·  01 Dec 2018  ·  doi:10.1001/jamaoncol.2018.4292

2017

A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors
A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors
Ioannis I. Verginadis, Rahul Kanade, Brett Bell, Sravya Koduri, Edgar Ben-Josef, Constantinos Koumenis
Cancer Research  ·  14 Feb 2017  ·  doi:10.1158/0008-5472.CAN-16-2724